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Article

The genetic variations in DNA repair genes ERCC2 and XRCC1 were associated with the overall survival of advanced non-small-cell lung cancer patients.

Cancer medicine - 1 Sept 2016

Wang Suhan, Wang Jianzhong, Bai Yansen, Wang Qing, Liu Li, Zhang Kai, Hong Xiaohua, Deng Qifei, Zhang Xiaomin, He Meian, Wu Tangchun, Xu Ping, Guo Huan

Abstract excerpt

It was reported that DNA repair can confer cancer cell resistance to therapeutic treatments by activating antiapoptotic cellular defense. We hypothesized that genetic variants of DNA repair genes may be associated with lung cancer prognosis. Seventeen tagging single-nucleotide polymorphism (tagSNPs) selected from 12 DNA repair genes were genotyped in 280 advanced non-small-cell lung cancer (NSCLC) patients by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27465648
DOI: 10.1002/cam4.822
PMCID: PMC5055187

Genes

ERCC2
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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