Article

Targeting the Human Papillomavirus 16 E6 Oncoprotein with Antibodies

2022-10-22

Abstract excerpt

The human papillomavirus (HPV) 16 genome encodes two oncoproteins, E6 and E7, which are essential for viral carcinogenesis. While E7 promotes cell proliferation, E6 abolishes the resulting p53-dependent apoptotic response. Due to this specific function, E6 is considered a suitable target for the development of a variety of therapeutic agents such as antibodies. Here, we review anti-E6 antibodies/antibody fragments...

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Literature Corpus work: ca29a205-21da-58bd-a316-77c37b142649
DOI: 10.1101/2022.10.21.513107

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