Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Caspase‐mediated programmed cell death pathways as potential therapeutic targets in cancer

20 Mar 2012

Abstract excerpt

The caspase family is well characterized as playing a crucial role in modulation of programmed cell death (PCD), which is a genetically regulated, evolutionarily conserved process with numerous links to many human diseases, most notably cancer. In this review, we focus on summarizing the intricate relationships between some members of the caspase family and their key apoptotic mediators, involving tumour necrosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cell death mechanisms and regulation
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22429822
DOI: 10.1111/j.1365-2184.2012.00814.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Caspase‐mediated programmed cell death pathways as potential therapeutic targets in cancerPMID 22429822Read ↗

Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer TherapeuticsSemantic proximity Read ↗

Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?Semantic proximity Read ↗

Apoptosis and cancer: mutations within caspase genes.Semantic proximity Read ↗

Molecular Mechanisms of Apoptosis and Roles in Cancer Development and TreatmentSemantic proximity Read ↗

Programmed cell death: many ways for cells to die decentlySemantic proximity Read ↗

Understanding Apoptosis and Apoptotic Pathways Targeted Cancer TherapeuticsSemantic proximity Read ↗

The Bcl-2-regulated apoptotic pathwaySemantic proximity Read ↗

Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosisSemantic proximity Read ↗

Mitochondria-mediated apoptosis in mammalsSemantic proximity Read ↗

The Molecular Machinery Regulating Apoptosis Signal Transduction and its Implication in Human Physiology and PathophysiologiesSemantic proximity Read ↗

Caspases: potential targets for regulating cell deathSemantic proximity Read ↗

Caspases: An apoptosis mediatorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.