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Article

Genetic Variations in the Promoter of the APE1 Gene Are Associated with DMF-Induced Abnormal Liver Function: A Case-Control Study in a Chinese Population.

International journal of environmental research and public health - 25 Jul 2016

Tong Zhimin, Shen Huanxi, Yang Dandan, Zhang Feng, Bai Ying, Li Qian, Shi Jian, Zhang Hengdong, Zhu Baoli

Abstract excerpt

Acute or long-term exposure to N,N-dimethylformamide (DMF) can induce abnormal liver function. It is well known that DMF is mainly metabolized in the liver and thereby produces reactive oxygen species (ROS). The base excision repair (BER) pathway is regarded as a very important pathway involved in repairing ROS-induced DNA damage. Several studies have explored the associations between GSTM1, GSTT1, CYP2E1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemical and Drug Induced Liver Injury

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Share to Polymorphism, Genetic

Source

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Identifiers

PMID: 27463724
DOI: 10.3390/ijerph13080752
PMCID: PMC4997438

Genes

XRCC1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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