Article
Correlation between CAT polymorphism and susceptibility to DMAc-induced abnormal liver function: a case-control study of Chinese population.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Mar 2018
Song Xianping, Gong Wei, Shen Huanxi, Li Xiuting, Ding Lu, Han Lei, Zhang Hengdong, Zhu Baoli, Liu Xin
Abstract excerpt
CONTEXT: Acute or chronic exposure of N,N-dimethylacetamide (DMAc) is responsible for abnormal liver function. It appears that DMAc is mainly metabolized by cytochrome P450 in the liver and thereby produces reactive oxygen species (ROS). The elimination of ROS and the repairing of ROS-induced DNA damage are relevant to the ultimate toxicity of DMAc. OBJECTIVE: To investigate whether the polymorphisms in the CAT...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.