Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.

The Journal of clinical endocrinology and metabolism - 1 Nov 2008

Schweppe Rebecca E, Klopper Joshua P, Korch Christopher, Pugazhenthi Umarani, Benezra Miriam, Knauf Jeffrey A, Fagin James A, Marlow Laura A, Copland John A, Smallridge Robert C, Haugen Bryan R

Abstract excerpt

CONTEXT: Cell lines derived from human cancers provide critical tools to study disease mechanisms and develop novel therapies. Recent reports indicate that up to 36% of cell lines are cross- contaminated. OBJECTIVE: We evaluated 40 reported thyroid cancer-derived cell lines using short tandem repeat and single nucleotide polymorphism array analysis. RESULTS: Only 23 of 40 cell lines tested have unique genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Follicular
Share to Cell Culture Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to DNA, Neoplasm

Share to Melanoma

Share to Neoplasm Proteins

Share to Reproducibility of Results

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 18713817
DOI: 10.1210/jc.2008-1102
PMCID: PMC2582569

Genes

KAT5
KAT7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.PMID 18713817Read ↗

Investigation of Cross-Contamination and Misidentification of 278 Widely Used Tumor Cell LinesSemantic proximity Read ↗

Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts.Semantic proximity Read ↗

A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian carcinoma cells.Semantic proximity Read ↗

A Combination of Species Identification and STR Profiling Identifies Cross-contaminated Cells from 482 Human Tumor Cell LinesSemantic proximity Read ↗

Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from HeLa.Semantic proximity Read ↗

A resource for cell line authentication, annotation and quality control.Semantic proximity Read ↗

Hiding in Plain View: Genetic Profiling Reveals Decades Old Cross Contamination of Bladder Cancer Cell Line KU7 with HeLaSemantic proximity Read ↗

Thyroid cancer cell line misidentification: an update.Semantic proximity Read ↗

Optimization of cell lines as tumour models by integrating multi-omics data.Semantic proximity Read ↗

Genomic complexity and targeted genes in anaplastic thyroid cancer cell lines.Semantic proximity Read ↗

Cancer Cell Lines Are Useful Model Systems for Medical ResearchSemantic proximity Read ↗

A comprehensive transcriptional portrait of human cancer cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.