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Article

The effects of genomic polymorphisms in one-carbon metabolism pathways on survival of gastric cancer patients received fluorouracil-based adjuvant therapy.

Scientific reports - 26 Jul 2016

Zhao Tingting, Xu Zhi, Gu Dongying, Wu Peng, Huo Xinying, Wei Xiaowei, Tang Yongfei, Gong Weida, He Ming-Liang, Chen Jinfei

Abstract excerpt

5-fluorouracil (5-FU) is widely used to treat patients with gastric cancer (GC). However, the response rate is quite heterogeneous. The single nucleotide polymorphisms (SNPs) and their interactions of genes in the one-carbon metabolism (OCM) pathway, including Methylenetetrahydrofolate reductase (MTHFR), Methionine synthase reductase (MTRR), Methionine synthase (MTR), and Thymidylate synthase (TS), significantly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27456431
DOI: 10.1038/srep28019
PMCID: PMC4960563

Genes

MTRR
MTHFR
MTR
OCM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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