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Article

Evaluation of antiviral effects of novel NS5A inhibitors in hepatitis C virus cell culture system with full-genome infectious clones.

Antiviral research - 1 Oct 2018

Murayama Asako, Fujiwara Kei, Yamada Norie, Shiina Masaaki, Aly Hussein Hassan, Masaki Takahiro, Muramatsu Masamichi, Wakita Takaji, Kato Takanobu

Abstract excerpt

Nonstructural protein 5A (NS5A) inhibitors of hepatitis C virus (HCV) are known to have potent anti-viral effects; however, these inhibitors have limited activities on strains with resistant-associated substitutions or non-genotype 1 strains. To overcome these shortcomings, novel NS5A inhibitors have been developed and approved for clinical application. The aim of this study was to evaluate the anti-viral effect...

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PMID: 30118732
DOI: 10.1016/j.antiviral.2018.08.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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