Lack of association between ADRB2 (Gln27Glu) variant with susceptibility, severity and salbutamol response in South Indian asthmatics.

doi:10.1038/s41598-026-53042-0

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Lack of association between ADRB2 (Gln27Glu) variant with susceptibility, severity and salbutamol response in South Indian asthmatics.

Scientific reports - 21 May 2026

Bandaru Srinivas, Bodduluri Sudha, Swami Radhika, Chaudhary Rinku, Sharma Khushboo, Khan Arshiya, Sagurthi Someswar Rao, Gujjula Koteswara Reddy, Vemuri Praveen Kumar, Nayarisseri Anuraj

Abstract excerpt

ADRB2 gene polymorphisms have been widely studied for their role in influencing asthma pathophysiology. Of particular note, the Gln27Glu (+ 79 C > G, rs1042714) polymorphism, which alters the extracellular domain at the N-terminus of β2AR, leads to the expression of an immature protein. While this polymorphism has been studied in various ethnic groups, its relevance in South Indian asthmatics remains unexplored....

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PMID: 42168467
DOI: 10.1038/s41598-026-53042-0
PMCID: PMC13396444

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ADRB2

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