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Article

Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle.

Skeletal muscle - 1 Jan 2016

Roy Pauline, Rau Fredérique, Ochala Julien, Messéant Julien, Fraysse Bodvael, Lainé Jeanne, Agbulut Onnik, Butler-Browne Gillian, Furling Denis, Ferry Arnaud

Abstract excerpt

BACKGROUND: The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy. However, how these therapies reduce the muscle fragility is not clear. METHODS: To address this question, we first determined the event(s) of the excitation-contraction cycle which is/are...

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Identifiers

PMID: 27441081
DOI: 10.1186/s13395-016-0096-4
PMCID: PMC4952281

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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