Article

Dystrophin is a mechanical tension modulator

2022-12-23

Abstract excerpt

Duchenne muscular dystrophy (DMD) represents the most common inherited muscular disease, where progressing muscle weakness leads to loss of ambulation and premature death. DMD is caused by mutations in the dystrophin gene, and is known to reduce the contractile capacity of muscle tissue both in vivo , and in reconstituted systems in vitro . However, these observations are based on mechanical studies that focused...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c0522dd-4dd5-5b96-ab30-b31e56d9b0c0
DOI: 10.1101/2022.12.23.521750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dystrophin is a mechanical tension modulatorDOI 10.1101/2022.12.23.521750Read

Tissue-Engineered Skeletal Muscle Models to Study Muscle Function, Plasticity, and DiseaseSemantic proximity Read

Recent Trends in Biofabrication Technologies for Studying Skeletal Muscle Tissue-Related DiseasesSemantic proximity Read

Electrical stimulation of biofidelic engineered muscle enhances myotube size, force, fatigue resistance, and induces a fast-to-slow-phenotype shift.Semantic proximity Read

Stretched Exponential Modeling Reveals Drug-Specific Kinetics in Human Engineered Skeletal MuscleSemantic proximity Read

Multi-modal analysis of satellite cells reveals early impairments at pre-contractile stages of myogenesis in Duchenne muscular dystrophySemantic proximity Read

Muscle degeneration without mechanical injury in sarcoglycan deficiencySemantic proximity Read

Modelling in vivo skeletal muscle ageing in vitro using three‐dimensional bioengineered constructsSemantic proximity Read

Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytesSemantic proximity Read

Molecular and cellular adaptations to chronic myotendinous strain injury in mdx mice expressing a truncated dystrophin.Semantic proximity Read

Electrophysiological analysis of healthy and dystrophic 3D bioengineered skeletal muscle tissuesSemantic proximity Read

Acute microtubule changes linked to DMD pathology are insufficient to impair contractile function or enhance contraction-induced injury in healthy muscleSemantic proximity Read

Deleterious impacts of inactivity and beneficial impacts of neuromuscular electrical stimulation on muscle structure and function in the zebrafish model of Duchenne Muscular DystrophySemantic proximity Read