Article
Differential susceptibility of muscles to myotonia and force impairment in a mouse model of myotonic dystrophy.
Muscle & nerve - 1 Jun 2011
Moyer Michelle, Berger Dara S, Ladd Andrea N, Van Lunteren Erik
Abstract excerpt
INTRODUCTION: Myotonic dystrophy, or dystrophia myotonica (DM), is characterized by prominent muscle wasting and weakness as well as delayed muscle relaxation resulting from persistent electrical discharges. METHODS: We hypothesized heterogeneity among muscles in degree of weakness and myotonia in an expanded [(CUG)(250)] repeats transgenic (HSA(LR)) mouse DM model. Muscle contraction was compared among...
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