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Article

Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation.

Molecular vision - 1 Jan 2016

Igarashi Tsutomu, Miyake Koichi, Kobayashi Maika, Kameya Shuhei, Fujimoto Chiaki, Nakamoto Kenji, Takahashi Hisatomo, Igarashi Toru, Miyake Noriko, Iijima Osamu, Hirai Yukihiko, Shimada Takashi, Okada Takashi, Takahashi Hiroshi

Abstract excerpt

PURPOSE: We examined the neuroprotective effects of exogenous brain-derived neurotrophic factor (BDNF), which provides protection to retinal ganglion cells (RGCs) in rodents, in a model of transient intraocular pressure (IOP) elevation using a mutant (triple Y-F) self-complementary adeno-associated virus type 2 vector encoding BDNF (tm-scAAV2-BDNF). METHODS: The tm-scAAV2-BDNF or control vector encoding green...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27440998
PMCID: PMC4947967

Genes

BDNF
ERG
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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