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Article

Cumulative mtDNA damage and mutations contribute to the progressive loss of RGCs in a rat model of glaucoma.

Neurobiology of disease - 1 Feb 2015

Wu Ji-Hong, Zhang Sheng-Hai, Nickerson John M, Gao Feng-Juan, Sun Zhongmou, Chen Xin-Ya, Zhang Shu-Jie, Gao Feng, Chen Jun-Yi, Luo Yi, Wang Yan, Sun Xing-Huai

Abstract excerpt

Glaucoma is a chronic neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Mitochondrial DNA (mtDNA) alterations have been documented as a key component of many neurodegenerative disorders. However, whether mtDNA alterations contribute to the progressive loss of RGCs and the mechanism whereby this phenomenon could occur are poorly understood. We investigated mtDNA...

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Identifiers

PMID: 25478814
DOI: 10.1016/j.nbd.2014.11.014
PMCID: PMC4523228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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