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Repression of cell cycle–related proteins by oxaliplatin but not cisplatin in human colon cancer cells

1 Sept 2006

Abstract excerpt

Oxaliplatin (Eloxatin) is a third-generation platinum derivative with an in vitro and in vivo spectrum of activity distinct from that of cisplatin, especially in colon cancer cells. Here, we studied the molecular basis of this difference on the HCT-116 human colon carcinoma cell line (mismatch repair-deficient, wild-type functional p53). Oxaliplatin inhibited HCT-116 cell proliferation with greater efficacy than...

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PMID: 16985047
DOI: 10.1158/1535-7163.mct-05-0212

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