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Article

Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes

20 Jul 2016

Abstract excerpt

Current therapies for metastatic clear cell renal cell carcinoma (ccRCC) show limited efficacy. Drug efficacy, typically investigated in preclinical cell line models during drug development, is influenced by pharmacogenes involved in targeting and disposition of drugs. Here we show through genome-wide DNA methylation profiling, that methylation patterns are concordant between primary ccRCC and macro-metastases...

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PMID: 27435027
DOI: 10.1038/srep29930

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