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Article

SOX9 is an atypical intestinal tumor suppressor controlling the oncogenic Wnt/ß-catenin signaling.

Oncotarget - 13 Dec 2016

Prévostel Corinne, Rammah-Bouazza Cyrine, Trauchessec Hélène, Canterel-Thouennon Lucile, Busson Muriel, Ychou Marc, Blache Philippe

Abstract excerpt

SOX9 inactivation is frequent in colorectal cancer (CRC) due to SOX9 gene mutations and/or to ectopic expression of MiniSOX9, a dominant negative inhibitor of SOX9. In the present study, we report a heterozygous L142P inactivating mutation of SOX9 in the DLD-1 CRC cell line and we demonstrate that the conditional expression of a wild type SOX9 in this cell line inhibits cell growth, clonal capacity and...

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Identifiers

PMID: 27429045
DOI: 10.18632/oncotarget.10573
PMCID: PMC5347687

Genes

SOX9
DLD

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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