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Article

Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma.

Oncotarget - 9 Aug 2016

Javier Breanna M, Yaeger Rona, Wang Lu, Sanchez-Vega Francisco, Zehir Ahmet, Middha Sumit, Sadowska Justyna, Vakiani Efsevia, Shia Jinru, Klimstra David, Ladanyi Marc, Iacobuzio-Donahue Christine A, Hechtman Jaclyn F

Abstract excerpt

PURPOSE: The extent to which the developmental transcription factor SOX9 functions as an oncogene or tumor suppressor in colorectal carcinoma (CRC) is debatable. We aimed to clarify the effect of SOX9 mutations on SOX9 protein expression and their association with known molecular subtypes and clinical characteristics in advanced CRC. EXPERIMENTAL DESIGN: Next generation sequencing data (MSK-IMPACT) from CRC...

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Source

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Identifiers

PMID: 27248473
DOI: 10.18632/oncotarget.9682
PMCID: PMC5239443

Genes

SOX9
KRAS
APC
BRAF
IMPACT
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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