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Article

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

Nature neuroscience - 1 Nov 2016

Nott Alexi, Cheng Jemmie, Gao Fan, Lin Yuan-Ta, Gjoneska Elizabeta, Ko Tak, Minhas Paras, Zamudio Alicia Viridiana, Meng Jia, Zhang Feiran, Jin Peng, Tsai Li-Huei

Abstract excerpt

Mutations in MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). The RTT missense MECP2R306C mutation prevents MeCP2 from interacting with the NCoR/histone deacetylase 3 (HDAC3) complex; however, the neuronal function of HDAC3 is incompletely understood. We found that neuronal deletion of Hdac3 in mice elicited abnormal locomotor coordination, sociability and cognition. Transcriptional and chromatin...

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Source

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Identifiers

PMID: 27428650
DOI: 10.1038/nn.4347
PMCID: PMC5083138

Genes

HDAC3
MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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