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Article

Fragment Length of Circulating Tumor DNA.

PLoS genetics - 1 Jul 2016

Underhill Hunter R, Kitzman Jacob O, Hellwig Sabine, Welker Noah C, Daza Riza, Baker Daniel N, Gligorich Keith M, Rostomily Robert C, Bronner Mary P, Shendure Jay

Abstract excerpt

Malignant tumors shed DNA into the circulation. The transient half-life of circulating tumor DNA (ctDNA) may afford the opportunity to diagnose, monitor recurrence, and evaluate response to therapy solely through a non-invasive blood draw. However, detecting ctDNA against the normally occurring background of cell-free DNA derived from healthy cells has proven challenging, particularly in non-metastatic solid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27428049
DOI: 10.1371/journal.pgen.1006162
PMCID: PMC4948782

Genes

BRAF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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