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Fragment Enrichment of Circulating Tumor DNA With Low-Frequency Mutations

28 Feb 2020

Abstract excerpt

Human blood contains cell-free DNA (cfDNA), with circulating tumor-derived DNAs (ctDNAs) widely used in cancer diagnosis and treatment. However, it is still difficult to efficiently and accurately identify and distinguish specific ctDNAs from normal cfDNA in cancer patient blood samples. In this study, ctDNA fragment length distribution analysis showed that ctDNA fragments are frequently shorter than the normal...

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PMID: 32180799
DOI: 10.3389/fgene.2020.00147

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