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3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice

13 Sept 2022

Abstract excerpt

Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine (3DA), an S-adenosyl homocysteinase inhibitor, alleviates replicative and oncogene-induced senescence. 3DA-treated senescent cells showed reduced global histone H3 lysine 36 trimethylation, an...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 36438588
DOI: 10.1038/s43587-022-00279-9

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