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Article

Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start?

Seminars in immunopathology - 1 Jun 2017

Tracy Alexander, Buckley Christopher D, Raza Karim

Abstract excerpt

It is well recognised that a state of autoimmunity, in which immunological tolerance is broken, precedes the development of symptoms in the majority of patients with rheumatoid arthritis (RA). For individuals who will later develop seropositive disease, this manifests as autoantibodies directed against proteins that have undergone specific post-translational modifications. There is evidence that the induction of...

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Identifiers

PMID: 28337522
DOI: 10.1007/s00281-017-0620-6
PMCID: PMC5486797

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