Article

Kinetic and Redox Characterization of KRAS G12C Inhibition

2022-04-03

Abstract excerpt

<h4>ABSTRACT</h4> The development of mutant-selective inhibitors for the KRAS G12C allele has generated considerable excitement. These KRAS G12C inhibitors covalently engage the mutant C12 thiol located within the phosphoryl binding loop of RAS, locking the KRAS G12C protein in an inactive state. While clinical trials of these inhibitors have been promising, mechanistic questions regarding the reactivity of t...

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Literature Corpus work: b079f2b3-d9c9-50b3-bf37-38ffc32c41f4
DOI: 10.1101/2022.04.03.486828

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