Article

SHP-2 deletion in CD4+ chondrocyte precursors leads to tumor development with wrist tropism

2021-04-21

Abstract excerpt

Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine phosphatase SHP-2 (encoded by Ptpn11 ) is not required for T cell development. However, Ptpn11 gene deletion driven by CD4 Cre recombinase leads to cartilage tumors in the wrist. Using a fate mapping system, we demonstrate that wrist tumor development correlates with increased frequency and numbers of non-hematopoietic CD45 neg...

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Literature Corpus work: 17470f25-5c2a-5b08-a9ca-13f0e68d1f32
DOI: 10.21203/rs.3.rs-429721/v1

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