Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

18 Oct 2007

Abstract excerpt

Malignant fibrous histiocytoma (MFH), now termed high-grade undifferentiated pleomorphic sarcoma, is a commonly diagnosed mesenchymal tumor, yet both the underlying molecular mechanisms of tumorigenesis and cell of origin remain unidentified. We present evidence demonstrating that human mesenchymal stem cells (hMSCs) are the progenitors of MFH. DKK1, a Wnt inhibitor and mediator of hMSC proliferation, is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Sarcoma Diagnosis and Treatment
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17948129
DOI: 10.1172/jci31377

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathwayPMID 17948129Read ↗

A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells.Semantic proximity Read ↗

Concise Review: Mesenchymal Tumors: When Stem Cells Go MadSemantic proximity Read ↗

Distinct and Overlapping Sarcoma Subtypes Initiated from Muscle Stem and Progenitor CellsSemantic proximity Read ↗

The KrasG12D;Trp53fl/fl murine model of undifferentiated pleomorphic sarcoma is macrophage dense, lymphocyte poor, and resistant to immune checkpoint blockade.Semantic proximity Read ↗

Muscle Stem Cells Give Rise to Rhabdomyosarcomas in a Severe Mouse Model of Duchenne Muscular DystrophySemantic proximity Read ↗

Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cellsSemantic proximity Read ↗

MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma with direct translational applicationsSemantic proximity Read ↗

Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.Semantic proximity Read ↗

Unveiling the role of KSHV‐infected human mesenchymal stem cells in Kaposi's sarcoma initiationSemantic proximity Read ↗

Establishment and characterization of PUMC-DDCS1: a novel patient-derived cell line of dedifferentiated chondrosarcomaSemantic proximity Read ↗

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans ProgressivaSemantic proximity Read ↗

Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi’s Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming PhenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.