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Ex vivo expanded regulatory T cells CD4+CD25+FoxP3+CD127Low develop strong immunosuppressive activity in patients with remitting-relapsing multiple sclerosis.

Autoimmunity - 1 Sept 2016

Lifshitz Gelena V, Zhdanov Dmitry D, Lokhonina Anastasia V, Eliseeva Daria D, Lyssuck Elena Y, Zavalishin Igor A, Bykovskaia Svetlana N

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease characterized by defect in regulatory function of CD4+CD25+ T cells. We demonstrated difference in proportion of regulatory T cells CD4+CD25+FoxP3+CD127low (Tregs) within the same patients' relapse and remission. Proportion of peripheral Tregs (pTregs) dropped almost two times in the relapse compare to remission. Levels of pTregs in patients' remission were lower...

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PMID: 27424664
DOI: 10.1080/08916934.2016.1199020

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