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Ex Vivo Generated Regulatory T Cells Modulate Experimental Autoimmune Myasthenia Gravis

1 Feb 2008

Abstract excerpt

Naturally occurring CD4(+)CD25(+) regulatory T (Treg) cells are key players in immune tolerance and have therefore been suggested as potential therapeutic tools for autoimmune diseases. In myasthenia gravis (MG), reduced numbers or functionally impaired Treg cells have been reported. We have observed that PBL from myasthenic rats contain decreased numbers of CD4(+)CD25(high)Foxp3(+) cells as compared with PBL...

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PMID: 18250419
DOI: 10.4049/jimmunol.180.4.2132

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