Article
PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption.
EBioMedicine - 1 Aug 2016
Stechschulte L A, Czernik P J, Rotter Z C, Tausif F N, Corzo C A, Marciano D P, Asteian A, Zheng J, Bruning J B, Kamenecka T M, Rosen C J, Griffin P R, Lecka-Czernik B
Abstract excerpt
The peroxisome proliferator-activated receptor gamma (PPARγ) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. However, clinical use of TZDs has been limited by side effects including a higher risk of fractures and bone loss. Here we demonstrate that the same...
Topics
- Adipocytes
- Animals
- Bone Resorption
- Bone and Bones
- Cell Line
- Energy Metabolism
- Male
- Mice
- Models, Animal
- Mutation
- Osteoblasts