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Article

Protein component of the ribozyme ribonuclease P alters substrate recognition by directly contacting precursor tRNA.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998

Niranjanakumari S, Stams T, Crary S M, Christianson D W, Fierke C A

Abstract excerpt

The protein component of ribonuclease P (RNase P) binds to the RNA subunit, forming a functional ribonucleoprotein complex in vivo and enhancing the affinity of the precursor tRNA (pre-tRNA) substrate. Photocrosslinking experiments with pre-tRNA bound to RNase P reconstituted with the protein component of Bacillus subtilis ribonuclease P (P protein) site specifically modified with a crosslinking reagent indicate...

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Identifiers

PMID: 9860948
DOI: 10.1073/pnas.95.26.15212
PMCID: PMC28022

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