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Article

Identification and Preclinical Testing of Novel Antiepileptic Compounds

1 Sept 1997

Abstract excerpt

Procedures for identifying novel antiepileptic drugs (AEDs) are changing and need to change more. Widespread reliance on two primary screens has led to the identification of novel compounds that resemble either phenytoin (suppressing high-frequency repetitive firing in cultured neurons and prolonging inactivation of voltage-dependent sodium channels identified by the maximal electroshock test) or benzodiazepines...

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PMID: 9578540
DOI: 10.1111/j.1528-1157.1997.tb05204.x

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