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Article

Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins

19 Jul 2011

Abstract excerpt

Cancer cells are hypersensitive to nutrient limitation because oncogenes constitutively drive glycolytic and TCA (tricarboxylic acid) cycle intermediates into biosynthetic pathways. As the anaplerotic reactions that replace these intermediates are fueled by imported nutrients, the cancer cell's ability to generate ATP becomes compromised under nutrient-limiting conditions. In addition, most cancer cells have...

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PMID: 21767261
DOI: 10.1042/bj20110853

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