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Article

Changes in O-Linked N-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells.

The Journal of biological chemistry - 2 Sept 2016

de Queiroz Rafaela Muniz, Madan Rashna, Chien Jeremy, Dias Wagner Barbosa, Slawson Chad

Abstract excerpt

O-GlcNAcylation is a dynamic post-translational modification consisting of the addition of a single N-acetylglucosamine sugar to serine and threonine residues in proteins by the enzyme O-linked β-N-acetylglucosamine transferase (OGT), whereas the enzyme O-GlcNAcase (OGA) removes the modification. In cancer, tumor samples present with altered O-GlcNAcylation; however, changes in O-GlcNAcylation are not consistent...

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Source

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Identifiers

PMID: 27402830
DOI: 10.1074/jbc.M116.734533
PMCID: PMC5009264

Genes

OGA
OGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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