Article

O-GlcNAcylation inhibition redirects the response of colon cancer cells to chemotherapy from senescence to apoptosis

2024-06-13

Abstract excerpt

<title>Abstract</title> <p>The potential use of pro-senescence therapies, known as TIS (Therapy-Induced Senescence), for the treatment of colorectal cancer (CRC) generated significant interest since they require lower doses compared to those required for inducing apoptosis. However, the senescent cell cycle-arrested cancer cells are long-lived, and studies have revealed escape mechanisms contributing to tumor rec...

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Literature Corpus work: b3879608-d474-5b84-9fd3-f0c90abc9332
DOI: 10.21203/rs.3.rs-4376125/v1

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