Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro.

Biotechnology and applied biochemistry - 1 Nov 2016

Zhang Nuobei, Chen Xin

Abstract excerpt

O-GlcNAcylation is a monosaccharide modification by a residue of N-acetylglucosamine (GlcNAc) attached to serine or threonine moieties on nuclear and cytoplasmic proteins. O-GlcNAcylation is dynamically regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Increasing evidence suggests that O-GlcNAcylation is involved in a variety of human cancers. However, the exact role of O-GlcNAcylation in tumor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylglucosamine
Share to beta-N-Acetylhexosaminidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromones

Share to Morpholines

Share to N-Acetylglucosaminyltransferases

Share to Oncogenes

Share to Proto-Oncogene Proteins c-akt

Share to Serine

Source

Identifiers

PMID: 26333304
DOI: 10.1002/bab.1441

Genes

OGT
OGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Potential role of O-GlcNAcylation and involvement of PI3K/Akt1 pathway in the expression of oncogenic phenotypes of gastric cancer cells in vitro.PMID 26333304Read ↗

GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway.Semantic proximity Read ↗

O-GlcNAcylation promotes malignant phenotypes of bladder cancer cells.Semantic proximity Read ↗

ST3GAL1 Promotes Malignant Phenotypes in Intrahepatic Cholangiocarcinoma.Semantic proximity Read ↗

O-GlcNAc Regulated Proliferation and Deterioration of the Nasal Inverted PapillomaSemantic proximity Read ↗

Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis.Semantic proximity Read ↗

β-1,4-Galactosyltransferase III suppresses β1 integrin-mediated invasive phenotypes and negatively correlates with metastasis in colorectal cancer.Semantic proximity Read ↗

Feedback Regulation of O-GlcNAc Transferase through Translation Control to Maintain Intracellular O-GlcNAc Homeostasis.Semantic proximity Read ↗

Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach.Semantic proximity Read ↗

Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation.Semantic proximity Read ↗

Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.Semantic proximity Read ↗

Cortactin expression confers a more malignant phenotype to gastric cancer SGC-7901 cells.Semantic proximity Read ↗

Elevated O-GlcNAcylation Promotes Malignant Phenotypes of Hypopharyngeal Squamous Cell Carcinoma by Stabilizing Nrf2 through Regulation of the PI3K/Akt Pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.