Article
Reversal of dendritic phenotypes in 16p11.2 microduplication mouse model neurons by pharmacological targeting of a network hub.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2016
Blizinsky Katherine D, Diaz-Castro Blanca, Forrest Marc P, Schürmann Britta, Bach Anthony P, Martin-de-Saavedra Maria Dolores, Wang Lei, Csernansky John G, Duan Jubao, Penzes Peter
Abstract excerpt
The architecture of dendritic arbors contributes to neuronal connectivity in the brain. Conversely, abnormalities in dendrites have been reported in multiple mental disorders and are thought to contribute to pathogenesis. Rare copy number variations (CNVs) are genetic alterations that are associated with a wide range of mental disorders and are highly penetrant. The 16p11.2 microduplication is one of the CNVs...
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