Article
RET mutation and increased angiogenesis in medullary thyroid carcinomas.
Endocrine-related cancer - 1 Aug 2016
Verrienti Antonella, Tallini Giovanni, Colato Chiara, Boichard Amélie, Checquolo Saula, Pecce Valeria, Sponziello Marialuisa, Rosignolo Francesca, de Biase Dario, Rhoden Kerry, Casadei Gian Piero, Russo Diego, Visani Michela, Acquaviva Giorgia, Ferdeghini Marco, Filetti Sebastiano, Durante Cosimo
Abstract excerpt
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis. Response rates vary widely, and toxic effects are common, so treatment should be reserved for MTCs likely to be responsive to these drugs. RET mutations are common in MTCs, but it is unclear how they influence the microvascularization of these tumors. We...
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