Article
Influence of RET mutations on the expression of tyrosine kinases in medullary thyroid carcinoma.
Endocrine-related cancer - 1 Aug 2013
Rodríguez-Antona Cristina, Muñoz-Repeto Iván, Inglada-Pérez Lucia, de Cubas Aguirre A, Mancikova Veronika, Cañamero Marta, Maliszewska Agnieszka, Gómez Alvaro, Letón Rocío, Leandro-García Luis J, Comino-Méndez Iñaki, Sanchez Lara, Alvarez-Escolá Cristina, Aller Javier, Cascón Alberto, Robledo Mercedes
Abstract excerpt
The therapeutic options for patients with metastatic medullary thyroid carcinoma (MTC) have recently increased due to the development of tyrosine kinase inhibitors (TKIs), some of which have achieved remarkable clinical responses in MTC patients. However, the molecular basis for the large variability in TKI responses is unknown. In this exploratory study, we investigated the expression of eight key TKI target...
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