Article
The importance of the RET gene in thyroid cancer and therapeutic implications.
Nature reviews. Endocrinology - 1 May 2021
Salvatore Domenico, Santoro Massimo, Schlumberger Martin
Abstract excerpt
Since the discovery of the RET receptor tyrosine kinase in 1985, alterations of this protein have been found in diverse thyroid cancer subtypes. RET gene rearrangements are observed in papillary thyroid carcinoma, which result in RET fusion products. By contrast, single amino acid substitutions and small insertions and/or deletions are typical of hereditary and sporadic medullary thyroid carcinoma. RET...
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