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Article

Phosphorylation of Ku70 subunit by cell cycle kinases modulates the replication related function of Ku heterodimer.

Nucleic acids research - 19 Sept 2016

Mukherjee Soumita, Chakraborty Prabal, Saha Partha

Abstract excerpt

The Ku protein, a heterodimer of Ku70 and Ku80, binds to chromosomal replication origins maximally at G1-phase and plays an essential role in assembly of origin recognition complex. However, the mechanism regulating such a critical periodic activity of Ku remained unknown. Here, we establish human Ku70 as a novel target of cyclin B1-Cdk1, which phosphorylates it in a Cy-motif dependent manner. Interestingly,...

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Identifiers

PMID: 27402161
DOI: 10.1093/nar/gkw622
PMCID: PMC5027504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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