Article
A cognitive fMRI study in non-manifesting LRRK2 and GBA carriers.
Brain structure & function - 1 Apr 2017
Bregman Noa, Thaler Avner, Mirelman Anat, Helmich Rick C, Gurevich Tanya, Orr-Urtreger Avi, Marder Karen, Bressman Susan, Bloem Bastiaan R, Giladi Nir
Abstract excerpt
Mutations in the GBA and LRRK2 genes account for one-third of the prevalence of Parkinson's disease (PD) in Ashkenazi Jews. Non-manifesting carriers (NMC) of these mutations represent a population at risk for future development of PD. PD patient who carry mutations in the GBA gene demonstrates more significant cognitive decline compared to idiopathic PD patients. We assessed cognitive domains using fMRI among NMC...
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