Article
Intact working memory in non-manifesting LRRK2 carriers--an fMRI study.
The European journal of neuroscience - 1 Jan 2016
Thaler Avner, Helmich Rick C, Or-Borichev Ayelet, van Nuenen Bart F L, Shapira-Lichter Irit, Gurevich Tanya, Orr-Urtreger Avi, Marder Karen, Bressman Susan, Bloem Bastiaan R, Giladi Nir, Hendler Talma, Mirelman Anat
Abstract excerpt
Cognitive impairments are prevalent in patients with Parkinson's disease. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of genetic Parkinsonism. Non-manifesting carriers of the G2019S mutation in the LRRK2 gene were found to have lower executive functions as measured by the Stroop task. This exploratory study aimed to assess whether the cognitive impairment in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.