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Article

Sudden cardiac arrest associated with use of a non-cardiac drug that reduces cardiac excitability: evidence from bench, bedside, and community.

European heart journal - 1 May 2013

Bardai Abdennasser, Amin Ahmad S, Blom Marieke T, Bezzina Connie R, Berdowski Jocelyn, Langendijk Pim N J, Beekman Leander, Klemens Christine A, Souverein Patrick C, Koster Rudolph W, de Boer Anthonius, Tan Hanno L

Abstract excerpt

AIMS: Non-cardiac drugs that impair cardiac repolarization (electrocardiographic QT prolongation) are associated with an increased sudden cardiac arrest (SCA) risk. Emerging evidence suggests that non-cardiac drugs that impair cardiac depolarization and excitability (electrocardiographic QRS prolongation) also increase the risk for SCA. Nortriptyline, which blocks the SCN5A-encoded cardiac sodium channel, may...

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Identifiers

PMID: 23425522
DOI: 10.1093/eurheartj/eht054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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