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Article

ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus.

Neurology - 23 Apr 2013

Shinohara Mayu, Saitoh Makiko, Nishizawa Daisuke, Ikeda Kazutaka, Hirose Shinichi, Takanashi Jun-ichi, Takita Junko, Kikuchi Kenjiro, Kubota Masaya, Yamanaka Gaku, Shiihara Takashi, Kumakura Akira, Kikuchi Masahiro, Toyoshima Mitsuo, Goto Tomohide, Yamanouchi Hideo, Mizuguchi Masashi

Abstract excerpt

OBJECTIVE: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a childhood encephalopathy following severe febrile seizures, leaving neurologic sequelae in many patients. However, its pathogenesis remains unclear. In this study, we clarified that genetic variation in the adenosine A2A receptor (ADORA2A), whose activation is involved in excitotoxicity, may be a predisposing factor of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 23535492
DOI: 10.1212/WNL.0b013e31828f18d8
PMCID: PMC3662331

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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