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Article

Analysis of association of ADORA2A and ADORA3 polymorphisms genotypes/haplotypes with efficacy and toxicity of methotrexate in patients with Rheumatoid arthritis.

The pharmacogenomics journal - 1 Dec 2020

Grk Milka, Milic Vera, Dolzan Vita, Maksimovic Nela, Damnjanovic Tatjana, Pjevic Marija Dusanovic, Pesic Milica, Novakovic Ivana, Jekic Biljana

Abstract excerpt

Adenosine receptors ADORA2A and ADORA3 are part of the adenosine-mediated antiinflammatory pathway and are overexpressed in patients with Rheumatoid arthritis (RA). Methotrexate (MTX) antiinflammatory effects are partially mediated via increased release of adenosine into extracellular space. Polymorphisms in ADORA2A and ADORA3 genes may have an impact on the efficacy and toxicity of MTX in RA patients. The study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32448869
DOI: 10.1038/s41397-020-0168-z

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