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Deletion of a dehydratase important for intracellular growth and cording renders rough <i>Mycobacterium abscessus</i> avirulent

6 Jul 2016

Abstract excerpt

Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer to a rough (R) low-GPL producer is associated with increased virulence in zebrafish, which involves the formation of massive serpentine cords, abscesses, and rapid larval death. Generating a cord-deficient Mabs mutant would allow us to address...

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PMID: 27385830
DOI: 10.1073/pnas.1605477113

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