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Article

Association of Hypoxia-Inducible Factor-2 Alpha Gene Polymorphisms with the Risk of Hepatitis B Virus-Related Liver Disease in Guangxi Chinese: A Case-Control Study.

PloS one - 1 Jan 2016

Huang Liling, Liu Cunxu, Deng Yan, Liu Yanqiong, Zhao Jiangyang, Huang Xiuli, Tang Wenjun, Sun Yifan, Qin Xue, Li Shan

Abstract excerpt

OBJECTIVE: Hypoxia-inducible factor-2 alpha (HIF-2a) plays a major role in the progression of disease, although the role of HIF-2α gene polymorphisms in hepatitis B virus (HBV)-related diseases remains elusive. The aim of this study is to determine whether HIF-2a rs13419896 and rs6715787 single-nucleotide polymorphisms (SNPs) are associated with susceptibility to chronic hepatitis B (CHB), liver cirrhosis (LC),...

Topics

Adult
Alcohol Drinking
Alleles
Asian People
Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Carcinoma, Hepatocellular

Case-Control Studies

China

Female

Fibrosis

Genetic Predisposition to Disease

Genotype

Haplotypes

Hepatitis B virus

Hepatitis B, Chronic

Humans

Liver Diseases

Liver Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27384772
DOI: 10.1371/journal.pone.0158241
PMCID: PMC4934873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27384772-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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