Article
Genetic polymorphisms in hypoxia-inducible factor-1a gene and its association with HBV-related hepatocellular carcinoma in a Chinese population.
Medical oncology (Northwood, London, England) - 1 Oct 2014
Liu Yanqiong, Sui Jingzhe, Zhai Limin, Yang Shi, Huang Li, Huang Liying, Mo Cuiju, Wu Junrong, Li Shan, Qin Xue
Abstract excerpt
Previous studies have demonstrated that hypoxia-inducible factor-1a (HIF-1a) may play a vital role in the pathogenesis of hepatocellular carcinoma (HCC). However, the relationship between HIF-1a polymorphisms and HCC has not been thoroughly investigated. The aim of this study is to determine whether HIF-1a polymorphisms are associated with HCC through a case-control study. Two polymorphisms in the HIF-1a gene...
Topics
- Adult
- Aged
- Asian People
- Carcinoma, Hepatocellular
- Case-Control Studies
- China
- Female
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Hepatitis B