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Article

Cyclooxygenase-2 promoter polymorphism -899G/C is associated with hepatitis B-related liver cancer in a Chinese population of Gansu province.

Chinese medical journal - 1 Dec 2011

He Jian-Hong, Li Yu-Min, Zhang Quan-Bao, Ren Zhi-Jian, Li Xun, Zhou Wen-Ce, Zhang Hui, Meng Wen-Bo, He Wen-Ting

Abstract excerpt

BACKGROUND: Hepatitis B virus infection is closely related to hepatocellular carcinoma (HCC). Cyclooxygenase-2 (COX-2) is overexpressed in HCC and considered to play a role in hepatic carcinogenesis. In this study, we analyzed the polymorphism of COX-2 promoter -899G/C in healthy controls, chronic hepatitis B (CHB) patients, liver cirrhosis patients, and hepatocellular carcinoma (HCC) patients, to investigate the...

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PMID: 22340386

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