Association between hypoxia-inducible factor-1α gene polymorphisms and risk of chronic hepatitis B and hepatitis B virus-related liver cirrhosis in a Chinese population: a retrospective case-control study.

doi:10.1016/j.gene.2015.03.053

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Article

Association between hypoxia-inducible factor-1α gene polymorphisms and risk of chronic hepatitis B and hepatitis B virus-related liver cirrhosis in a Chinese population: a retrospective case-control study.

Gene - 10 Jun 2015

Lu Yu, Sui Jingzhe, Liu Yanqiong, Li Ruolin, Ma Liping, Zhang Xiaolian, Qin Xue, Li Shan

Abstract excerpt

BACKGROUND: Our recent study demonstrated a significant association between HIF-1α polymorphisms and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Since chronic hepatitis B (CHB), liver cirrhosis (LC), and HCC are progressive stages of chronic HBV infection, the aim of this stud...

Topics

Adult
Base Sequence
Case-Control Studies
China
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Hepatitis B, Chronic
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Liver Cirrhosis

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Polymorphism, Single Nucleotide

Retrospective Studies

Risk

Source

Open in PubMed

Identifiers

PMID: 25824382
DOI: 10.1016/j.gene.2015.03.053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25824382-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.